SULPHONE RESISTANCE IN LEPROSY PATlENTS 7 TAB LE I The growth of
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چکیده
Studies were undertaken t o confirm the occurrence o f resistant strains o f Myco. leprae in leprosy p atients who fail to resp ond to treatment with dapsone. In the first 3 years, 39 p atients who had highly active disease despite a long history of treatment were selected from our outpatient clinico A suspension of bacilli from an active lesion was injected in to the foot pads of a group of normal CBA mice. The mice were then fed varying doses of dapsone in the diet for several months. At harvest, multiplication had occurred in the presence of high doses of dapsone in 1 2 , at low dosage in 7 and only in the contrai graup in 1 4. There were 6 failed experiments. This demonstrates that 1 9 patients harboured My co. leprae to some extent resistant to dapsone. Observations on the clinicai manifestations and subsequent pragress are made and comp ared with reports from other centres.
منابع مشابه
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تاریخ انتشار 2014